Cannibidiol, or "CBD" is the non-intoxicating component of the cannabis plant that has significant medical benefits, but does not make people feel "high" and according to recent studies, counteracts Hyper-Sensitivity to THC in some cases. The fact that CBD-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria some experience from High THC Cannabis. Scientific and clinical research, much of which is sponsored by the US government, underscores CBD's potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders. CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere.
• All cannabinoids, including CBD, attach themselves to certain receptors in the body to produce their effects.
• The human body produces certain cannabinoids on its own. It has two receptors for cannabinoids, called CB1 receptors and CB2 receptors.
• CB1 receptors are found all around the body, but many of them are in the brain.
• The CB1 receptors in the brain deal with coordination and movement, pain, emotions and mood, thinking, appetite, and memories, among others. THC attaches to these receptors.
• CB2 receptors are more common in the immune system. They have an effect on inflammation and pain.
• It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids.
• People commonly use prescription or over-the-counter drugs to
relieve pain and stiffness, including chronic pain.
• Some people feel that CBD offers a more natural way to lower pain.
•A study published in the Journal of Experimental Medicine found that
CBD significantly reduced chronic inflammation and pain in some
mice and rats.
• The researchers suggest that CBD, the non-psychoactive compound
could be a new treatment for chronic pain.
• CBD is already in use for some conditions that cause chronic pain,
such as multiple sclerosis and fibromyalgia
• There is some promising evidence that CBD use may help people to
quit smoking. A pilot study posted to Addictive Behaviors found that
smokers who used an inhaler containing the compound CBD smoked
fewer cigarettes but did not have any additional craving for nicotine.
• Another similar study posted to Neurotherapeutics found that CBD
may be a promising substance for people who abuse opioids.
• Researchers noted that some symptoms experienced by patients
with substance use disorders may be reduced by CBD. These include
anxiety, mood symptoms, pain, and insomnia.
• These are early findings, but they suggest that CBD may be used to
avoid or reduce withdrawal symptoms.
• CBD is also being studied for its possible role in treating epilepsy and
• A review posted to Epilepsia noted that CBD has anti-seizure
properties and a low risk of side effects for people with epilepsy.
• Studies into CBD's effect on neurological disorders suggest that it
may help to treat many of the disorders that are linked to epilepsy,
such as neurodegeneration, neuronal injury, and psychiatric
• Another study posted to Current Pharmaceutical Design found that
CBD may have similar effects to certain antiopsychotic drugs, and that
it may be safe and effective in treating patients with schizophrenia.
• More research is needed to understand how this works, however.
• CBD has been studied for its use as an anti-cancer agent.
• A review posted to the British Journal of Clinical Pharmacology
notes that CBD appears to block cancer cells from spreading
around the body and invading an area entirely.
• The review indicates that CBD tends to suppress the growth of
cancer cells and promote the death of these cells.
• Researchers note that CBD may help in cancer treatment because
of its low toxicity levels. They call for it to be studied along with
standard treatments, to check for synergistic effects.
• Patients with chronic anxiety are often advised to avoid cannabis, as
THC can trigger or amplify anxiety and paranoia in some people.
• However, a review from Neurotherapeutics suggests that CBD may
help to reduce the anxiety felt by people with certain anxiety
• The researchers point to studies showing that CBD may reduce anxiety
behaviors in disorders such as: post-traumatic stress disorder
• general anxiety disorder, panic disorder, social anxiety disorder and
• The review notes that current medications for these disorders can
lead to additional symptoms and side effects, and that people may
stop taking the drugs because of these unwanted effects.
• CBD has not shown any adverse effects in these cases to date, and the
researchers call for CBD to be studied as a potential treatment
• Type 1 diabetes is caused by inflammation when the immune
system attacks cells in the pancreas.
• Recent research posted to Clinical Hemotheology and
Microcirculation found that CBD may ease the inflammation in the
pancreas in type 1 diabetes. This may be the first step in finding a
CBD-based treatment for type 1 diabetes.
• Another promising use for CBD is as a new treatment for acne.
Acne is caused, in part, by inflammation and overworked
sebaceous glands on the body.
• A recent study posted to the Journal of Clinical Investigation found
that CBD helps to lower the production of sebum that leads to
acne, partly because of its anti-inflammatory effect on the body.
• CBD could be a future treatment for acne vulgaris, the most
common form of acne.
Initial research published in the Journal of Alzheimer's Disease found
that CBD was able to prevent the development of social recognition
deficit in subjects.This means that CBD could potentially prevent
people in the early stages of Alzheimer's from losing their ability to
recognize the faces of people that they know. This is the first evidence
that CBD has potential to prevent Alzheimer's disease symptoms